A real pleasure to write an opinion piece for Cell Metabolism on the Vaeth Lab’s interesting study investigating novel mechanisms underlying metabolic control of transcription in lymphocytes. Here, Hochrein et al. identify a metabolic checkpoint controlling the transcriptional programming of effector CD4+ T cells. The authors show that GLUT3-mediated glucose import and ACLY-dependent acetyl-CoA generation control histone acetylation and, hence, the epigenetic imprinting of effector gene expression in differentiated effector CD4+ T cells. These findings suggest a novel therapeutic target for inflammation-associated diseases. Links to the papers are below.
