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c o f f e r l a b

center for molecular medicine × REGENERATIVE MEDICINE CENTER

 

cellularcommunication

our research IS driven by both fundamental and clinical questions intersecting the fields of cancer, immunology and stem cells. we work to identify pathways of (INTRA)cellular communication that can be targeted to selectively reprogram pathogenic cells. examples of CURRENT research areas include: 

- UNderstanding and manipulating INTERACTIONS BETWEEN IMMUNE CELLS & TUMOURS 

- transcriptional control of epithelial plasticity and metastasis

- Targeting deregulated T cells in autoimmune and graft-versus-host-disease

- Therapeutic use of mesenchymal stem cell-derived exosomES

BIOLOGICAL PROCESSES WE explore INCLUDE: TRANSCRIPTION, intracellular SIGNALING, EPIGENETIC regulation, cellular METABOLISM, anergy, AUTOPHAGY & METASTASIS.

Our research uses a broad range of state-of-the-art molecular and cell biological approaches, as well as in vivo and ex-vivo models of disease. This forms a translatable research program with close connection to our clinical collaborators.

We are part of the center for molecular medicine and Located at the Regenerative Medicine Center, UMC Utrecht.

 

Phone

+31 (0)30 212-1800

 

Location

Regenerative Medicine Center
Uppsalalaan 8
3584CT Utrecht

 

 

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Paul Coffer

Group Leader

Research Manager, Division LAB, UMC Utrecht

Chair, Utrecht University Regenerative Medicine PhD program

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Cornelieke Pals

Lab Manager

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Koen Braat

Senior Lecturer

Program Manager, Utrecht University Regenerative Medicine PhD program

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Magdalena Lorenowicz

Senior Scientist

Therapeutic application of stem cell-derived exosomes

see webpage for more details

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Guy Roukens

Senior Postdoc

Transcriptional control of the mammary tumor niche

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Enric Mocholi

Senior Postdoc

T cell metabolism, anergy and autophagy

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Laura Russo

RESEARCH ASSOCIATE

(De)regulation of immunometabolism in pediatric arthritis

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Alessandro Cutilli

PhD Student

Anergy and autophagy in T cell activation

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Cindy Frederiks

Technician

Understanding the role of SOX4 in breast cancer

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Sonia Arístin

PhD studenT

Regulatory T (Treg) cells and colorectal cancer



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Suzy Varderidou

POSTDOC (MAGDALENA LORENOWICZ)

MSC-derived exosomes

 

Masters Students and Visiting Scientists

Representative publications for current research themes:

1. Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells. Fleskens, V., Minutti, C., Wu, X., Wei, P., Pals, C.E.G.M., McCrae, J., Hemmers, S., Groenewold, V., Rudensky, A., Pan, F., Li, H., Zaiss, D. and Coffer, P.J. (2019) Cell Reports 26, 3600-3612.

2. Forkhead transcription factors as context-dependent regulators of lymphocyte homeostasis. Zaiss, D. and Coffer, P.J. (2018) Nature Reviews Immunology 18, 703-715.

3. SOX4-SMAD3 interaction redirects TGF-β-mediated transcriptional output in a context-dependent manner. Vervoort, S.J., Lourenco, A.R., Tufegdzic-Vidakovic, A., Sandoval, J.L., Rueda, O.M., Frederiks, C.,  Russell, R., Caldas, C., Bruna, A. and Coffer, P.J. (2018) Nucleic Acid Research 46, 9578-9590.

4. Autophagy is a tolerance-avoidance mechanism that modulates TCR-mediated signaling and cell metabolism to prevent the induction of T cell anergy. Mocholi, E., Dowling, S.D., Botbol, Y., Gruber, R.C., Ray, A.K., Vastert, S., Shafit-Zagardo, B., Coffer, P.J. and Macian, F. (2018) Cell Reports 24, 1136-1150.

5. Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis. Vervoort, S.J.,  de Jong, O.G.,  Vermeulen, J.F., Bella, L., Lourenco, A-R., Frederiks, C., Tufegdzic-Vidakovic, A., Russell, R., Moelans,C., van Amersfoort, M., Dallman, M.J., Bruna, A., Caldas, C., Nieuwenhuis, E., van der Wall, E., Derksen, P., van Diest, P., Lam, W. W-F., Verhaar, M., Mokry, M. and Coffer, P.J. eLife, Dec 3;7.

6. Bartels M, Govers AM, Fleskens V, Lourenço AR, Pals CE, Vervoort SJ, van Gent  R, Brenkman AB, Bierings MB, Ackerman SJ, van Loosdregt J, Coffer PJ. (2015) Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation. Blood. 125, 1782-92

          see also News & Views: Gombart, 2015. Blood 125,1688-90

7. Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY. (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504, 451-5

8. USP7/HAUSP-mediated stabilization of Foxp3 increases Treg suppressive capacity. van Loosdregt, J., Fleskens, V., Fu, J., Brenkman, A.J., Bekker, C.P.J., Pals, C.E.G.M., Meerding, J., Berkers, C.R., Barbi, J., Grone, A., Sijts, A.J.M., Maurice, M.M., Kalkhoven, E., Prakken, B.J., Ovaa, O., Pan, F., Zaiss, D.M.W. and Coffer, P.J. (2013) Immunity 39, 259-271 

          see also News & Views: Laurence et al, 2013. Immunity 39, 201-203

9. Canonical Wnt signaling negatively modulates T regulatory cell function. van Loosdregt, J., Fleskens, V., Tiemessen, M.T., Mokry, M., van Boxtel, R., Meerding, J., Pals, C.E.G.M., Kurek, D., Baert, M.R., Delmarre, E.M., Grone, A., Groot-Koerkamp, M.J., Sijts, A.A.M., Maurice, M.M., van Es, J.H., ten Berge, D., Holstege, F.C., Staal, F.J.T., Zaiss, D.M.W., Prakken, B.J. and Coffer, P.J.  (2013) Immunity 39, 298-310

10. Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. van der Vos, K.E., Eliasson, P., Proikas-Cezanne, T., Vervoort, S.J., van Boxtel, R., Putker M., van Zutphen, I.J., Mauthe, M., Zellmer, S., Pals, C., Verhagen, L.P., Groot-Koerkamp, M.J., Braat, A.K., Dansen, T.B., Holstege, F.C., Gebhardt, R., Burgering, B.M., Coffer, P.J. (2012) Nature Cell Biology 14,  829-37

          see also News & Views: Sandri, 2012. Nature Cell Biology 4, 786-788


Click here for a full list of publications

Contact Us

Regenerative Medicine Center, UMC Utrecht, Uppsalalaan 6, 3584CT Utrecht, The Netherlands

 
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